Cipla Launches India’s Only Inhaled Insulin, Afrezza®

Cipla announced the commercial launch of Afrezza® — the first and only ultra-rapid-acting inhaled insulin available in India — marking a major milestone in diabetes care. This launch introduces a needle-free alternative to traditional injectable insulin for adults with type 1 and type 2 diabetes, addressing one of the biggest barriers in insulin therapy: fear or discomfort with injections.(cipla.com)

What Is Afrezza®?

Afrezza® (insulin human) Inhalation Powder is a dry-powder insulin formulated to be inhaled through a small handheld inhaler. Developed and manufactured by the MannKind Corporation (USA), it delivers insulin via the lungs and begins lowering blood glucose in roughly 12 minutes, closely mirroring the body’s natural insulin response after meals. The product uses single-use cartridges that are loaded into the inhaler and activated by a simple breath — eliminating needles entirely for mealtime insulin.(cipla.com)

Why This Matters for India

India has one of the world’s largest diabetes populations, with an estimated over 10 crore (100 million+) adults living with the disease, many of whom eventually require insulin therapy. Traditional injectable insulin regimens — often multiple times per day — can result in poor adherence due to discomfort, inconvenience, and social stigma. Afrezza® aims to bridge this gap by offering a more convenient, user-friendly, and less invasive insulin option.(India Today)

How Afrezza® Works

  • 💨 Needle-free Delivery — Inhaled via a small device with single-use cartridges that dissolve quickly in the lungs.(Indian Pharma Post)
  • Rapid Action — Starts lowering blood glucose ~12 minutes after inhalation, acting faster than many injectable mealtime insulins.(cipla.com)
  • 🍽 Mealtime Control — Typically taken at the start of the largest meal, with dosing adjustable as needed.(cipla.com)

For type 1 diabetes patients, Afrezza® is used in combination with long-acting insulin, as it only serves as mealtime (prandial) insulin. It is not a substitute for basal insulin.(Afrezza)


Benefits and Challenges

Key Advantages

Needle-free and Less Painful: Ideal for patients with needle aversion or injection anxiety.(NewsX)
Faster Onset: Closely mimics the body’s natural insulin response after meals.(cipla.com)
Convenience: Portable, discreet, and rapid dosing that fits modern lifestyles.(Indian Pharma Post)

Considerations

Lung Health: Not suitable for patients with chronic lung conditions (e.g., asthma, COPD) — lung function assessment is recommended before use.(Afrezza)
Not a Complete Replacement: Does not eliminate the need for basal insulin in type 1 diabetes.(Afrezza)


Possible Pricing (India & Globally)

While official Indian price lists from Cipla are not widely published yet, here’s what current indications and similar markets suggest:

India (Indicative Retail Price)

  • On Indian pharmacy aggregator sites, Afrezza cartridges (e.g., 30-count 12 IU pack) are listed at about ₹4,500–₹4,600.(mrmed.in)

Note: Actual pricing in India may vary by region, pharmacy, dose strength (e.g., 4 IU, 8 IU, 12 IU), and any introductory pricing or insurance reimbursements.

U.S. / International Reference

  • In the U.S., Afrezza is often listed at around $99 (≈ ₹8,200) per box for 90 cartridges through certain direct programs, or higher (several hundred USD) via retail pharmacies.(eaglepharmacy.com)
  • Without insurance or discounts, U.S. cash prices can range significantly, often above $450–$590 (≈ ₹37,000–₹48,000) for a similar pack size.(SingleCare)

💡 These are approximate figures. Cipla’s local pricing strategy in India — likely to be competitive and tailored to the price-sensitive market — will be disclosed formally by pharmacies and clinics as the product becomes widely available.


The Road Ahead

Cipla is not only commercializing Afrezza® but also planning awareness campaigns and patient support programs to improve insulin adherence and reduce stigma around insulin therapy. This includes education on inhaled insulin use, guidance on dosing, and engagement with endocrinologists across urban and rural India.(cipla.com)

With India’s diabetes burden continuing to grow, Afrezza® represents a significant advancement in patient-centric care — potentially improving quality of life for millions managing diabetes daily.


Disclaimer

  • Pricing information is indicative and subject to change. Final prices in India will depend on Cipla’s official market rollout, pharmacy pricing, and any insurance coverage.
  • Always consult a healthcare provider or diabetes specialist before changing insulin regimens.


Disclaimer: This material, including advice, provides general information only for educational purposes. It is in no way a substitute for a qualified medical opinion. Always consult a specialist or your doctor for more details. fittofitter.com does not claim responsibility for this information.

 

World Stroke Day (October 29) - Raising Awareness to Save Lives

Introduction:

 

World Stroke Day is observed annually on October 29 to raise global awareness about stroke and emphasize the importance of its prevention, early detection, and treatment. A stroke, also known as a cerebrovascular accident, is a medical emergency that occurs when the blood supply to the brain is interrupted or reduced, leading to brain cell death. Strokes can have devastating effects on individuals, families, and communities, but they are also largely preventable and treatable. This day serves as a crucial reminder that timely intervention can significantly reduce the impact of stroke, saving lives and preventing long-term disability.



 


 Understanding Stroke: Causes and Types

 

Strokes occur when there is a disruption in the flow of blood to the brain, depriving brain tissue of oxygen and nutrients. This disruption can be caused by several factors, and strokes are generally classified into two main types:

 

1. Ischemic Stroke: This is the most common type, accounting for approximately 85% of all strokes. It occurs when a blood clot or other obstruction blocks the flow of blood to the brain. These blockages are often caused by fatty deposits in the blood vessels (atherosclerosis) or clots that form in the heart and travel to the brain.

 

2. Hemorrhagic Stroke: This occurs when a blood vessel in the brain bursts, leading to bleeding within or around the brain. Hemorrhagic strokes are typically caused by conditions such as high blood pressure, aneurysms, or trauma to the head. Although less common than ischemic strokes, hemorrhagic strokes tend to have more severe outcomes.

 

Another type of stroke is known as a Transient Ischemic Attack (TIA) or "mini-stroke," which involves a temporary interruption of blood flow to the brain. TIAs do not cause permanent damage, but they serve as a warning sign that a full-blown stroke may occur in the future if preventive measures are not taken.

 

 Stroke Risk Factors

 

Several risk factors increase the likelihood of experiencing a stroke, some of which are modifiable, while others are not. Understanding these factors can help in both prevention and early intervention:

 

1. Non-Modifiable Risk Factors:

   - Age: Stroke risk increases with age, particularly for individuals over the age of 55.

   - Gender: Men are more likely to suffer a stroke than women, though women are more likely to die from it.

   - Family History: A family history of stroke or cardiovascular disease increases an individual’s risk.

   - Previous Stroke or TIA: Individuals who have already experienced a stroke or TIA are at higher risk of having another stroke.

 

2. Modifiable Risk Factors:

   - High Blood Pressure: Hypertension is the leading cause of stroke, making blood pressure control essential for stroke prevention.

   - Diabetes: People with diabetes are more likely to suffer from strokes due to damage to the blood vessels over time.

   - High Cholesterol: Elevated levels of cholesterol can lead to the build-up of plaque in arteries, increasing stroke risk.

   - Smoking: Tobacco use significantly increases the risk of both ischemic and hemorrhagic strokes.

   - Obesity and Sedentary Lifestyle: Being overweight and inactive can contribute to many stroke risk factors, including high blood pressure, diabetes, and high cholesterol.

   - Excessive Alcohol Consumption: Drinking excessive amounts of alcohol raises blood pressure and increases the likelihood of stroke.

 

 Recognizing Stroke: FAST – The Key to Early Intervention

 

One of the most important messages conveyed on World Stroke Day is the need for immediate action when a stroke is suspected. Time is of the essence, and the acronym FAST helps people quickly identify the warning signs of a stroke:

 

- F – Face Drooping: Is one side of the face drooping or numb? Ask the person to smile to check for asymmetry.

- A – Arm Weakness: Is one arm weak or numb? Ask the person to raise both arms and see if one arm drifts downward.

- S – Speech Difficulty: Is the person’s speech slurred or hard to understand? Ask them to repeat a simple sentence, like “The sky is blue.”

- T – Time to Call Emergency Services: If any of these signs are present, it’s crucial to call emergency services immediately.

 

The sooner a person experiencing a stroke receives medical attention, the better the chances of minimizing brain damage and improving recovery outcomes. Delayed treatment can result in severe and irreversible neurological damage, so knowing the signs and acting quickly can make all the difference.

 

 Stroke Prevention: Lifestyle Changes and Medical Interventions

 

The majority of strokes can be prevented through a combination of lifestyle changes and medical interventions. Preventive measures focus on reducing modifiable risk factors and promoting cardiovascular health.

 

1. Blood Pressure Control: Managing high blood pressure is the most effective way to reduce stroke risk. Regular monitoring, medication adherence, and lifestyle adjustments (e.g., reducing salt intake) are crucial for keeping blood pressure in check.

 

2. Healthy Diet: A heart-healthy diet rich in fruits, vegetables, whole grains, lean proteins, and healthy fats can lower the risk of stroke. Reducing the intake of processed foods, trans fats, and excessive sugar is also important for stroke prevention.

 

3. Exercise: Regular physical activity helps maintain a healthy weight, lower blood pressure, improve cholesterol levels, and reduce the risk of diabetes. Even moderate exercise, such as walking for 30 minutes a day, can have a significant impact on stroke prevention.

 

4. Smoking Cessation: Quitting smoking dramatically reduces stroke risk. Within a few years of quitting, a former smoker’s risk of stroke can approach that of a non-smoker.

 

5. Diabetes Management: Controlling blood sugar levels through diet, exercise, and medication is vital for people with diabetes to prevent stroke.

 

6. Limiting Alcohol: Moderating alcohol consumption can lower the risk of stroke. The recommended limit is one drink per day for women and two drinks per day for men.

 

7. Cholesterol Management: Lowering LDL (bad) cholesterol through diet, exercise, and medications like statins can reduce plaque build-up in arteries, decreasing the risk of stroke.

 

8. Medications: For individuals at high risk of stroke, such as those with atrial fibrillation (an irregular heart rhythm) or previous stroke, doctors may prescribe blood-thinning medications (anticoagulants or antiplatelet drugs) to reduce the likelihood of clot formation.

 

 Post-Stroke Care and Rehabilitation

 

Recovery after a stroke varies widely depending on the severity of the stroke and how quickly treatment was administered. Early rehabilitation is critical in helping stroke survivors regain as much function as possible and improve their quality of life. Key components of post-stroke care include:

 

1. Physical Therapy: Stroke often affects mobility and coordination, and physical therapy helps patients regain strength, balance, and movement. It may involve exercises to improve walking, limb function, and flexibility.

 

2. Speech Therapy: Many stroke survivors experience difficulty speaking, understanding language, or swallowing. Speech therapy can help rebuild communication skills and improve swallowing function.

 

3. Occupational Therapy: Occupational therapy focuses on helping stroke survivors regain the ability to perform daily activities such as dressing, cooking, and self-care. It also involves cognitive rehabilitation to address memory, attention, and problem-solving difficulties.

 

4. Mental Health Support: Stroke survivors are at increased risk of developing depression and anxiety. Counseling, support groups, and medication can be important components of emotional and psychological recovery.

 

 Global Impact of Stroke

 

Stroke is a leading cause of death and disability worldwide, affecting millions of people every year. According to the World Health Organization (WHO), an estimated 15 million people suffer a stroke annually, of whom 5 million die and another 5 million are left permanently disabled. These statistics highlight the immense burden that stroke places on individuals, families, and healthcare systems globally.

 

The economic impact of stroke is also significant, with costs associated with long-term care, rehabilitation, lost productivity, and healthcare resources. In low- and middle-income countries, the burden is particularly heavy due to limited access to healthcare services and stroke prevention programs.

 

 World Stroke Day 2024 Theme: “Together, We Are Stronger”

 

The theme for World Stroke Day 2024 is “Together, We Are Stronger,” emphasizing the power of community, collaboration, and shared knowledge in combating stroke. This year’s campaign focuses on building networks of support for stroke survivors and their families, promoting awareness of stroke prevention and treatment, and advocating for better access to healthcare services worldwide.

 

By coming together as individuals, healthcare professionals, governments, and organizations, we can make strides in reducing the global impact of stroke. Education and awareness are at the core of this effort, empowering people to recognize the warning signs, take preventive measures, and seek timely medical attention.

 

 Conclusion

 

World Stroke Day is a reminder that stroke is a preventable and treatable condition, but time is critical when it occurs. Awareness of the risk factors, recognition of the warning signs using the FAST method, and taking steps to reduce the risk can save lives and improve recovery outcomes. On October 29, we stand together to raise awareness about stroke, promote prevention, and support those affected by this life-altering condition. Through education, collaboration, and early intervention, we can make a meaningful difference in the fight against stroke.

 

Disclaimer: This material, including advice, provides general information only for educational purposes. It is in no way a substitute for a qualified medical opinion. Always consult a specialist or your doctor for more details. fittofitter.com does not claim responsibility for this information.

 

World Psoriasis Day: Understanding, Raising Awareness, and Inspiring Action

Introduction

 

World Psoriasis Day, observed annually on October 29, serves as a crucial global event dedicated to raising awareness about psoriasis, a chronic autoimmune condition affecting millions of people worldwide. Established by the International Federation of Psoriasis Associations (IFPA), the day is designed to highlight the physical, emotional, and social challenges faced by those living with psoriasis. With the overarching goal of reducing stigma, increasing public understanding, and improving access to treatment, World Psoriasis Day encourages advocacy and solidarity for people who often experience discrimination due to visible skin symptoms.

 

What is Psoriasis?

 

Psoriasis is a chronic autoimmune disorder characterized by rapid skin cell production, leading to thick, red, scaly patches of skin. These patches, known as plaques, can appear anywhere on the body but are most commonly found on the scalp, elbows, knees, and lower back. The condition is not contagious, though its appearance can be alarming to those unfamiliar with it. Psoriasis affects about 2-3% of the global population, with severity ranging from mild cases, where it covers small areas, to more severe cases that can lead to joint pain and deformity, known as psoriatic arthritis.

 

While the exact cause of psoriasis remains unclear, research points to a combination of genetic and environmental factors. The immune system plays a significant role, as psoriasis occurs when the body's immune cells mistakenly attack healthy skin cells. Triggers such as infections, stress, smoking, alcohol, and certain medications can also exacerbate the condition, causing flare-ups.

 


Types of Psoriasis

 

There are several different types of psoriasis, each with its unique presentation:

 

1. Plaque Psoriasis (Psoriasis Vulgaris): The most common form, plaque psoriasis appears as raised, inflamed, red lesions covered with silvery-white scales. It accounts for about 80-90% of all psoriasis cases.

  

2. Guttate Psoriasis: This type is more common in children and young adults. It presents as small, drop-shaped lesions, often triggered by bacterial infections such as strep throat.

 

3. Inverse Psoriasis: Found in skin folds such as the armpits, groin, and under the breasts, inverse psoriasis appears as smooth, red patches without the scales characteristic of other forms.

 

4. Pustular Psoriasis: A rare but severe form, pustular psoriasis causes white pustules surrounded by red skin. It can be localized to specific areas or widespread and often requires immediate medical attention.

 

5. Erythrodermic Psoriasis: The least common but most dangerous form, erythrodermic psoriasis causes widespread redness, itching, and peeling of the skin. This type can disrupt the body's ability to regulate temperature and fluid retention, potentially leading to life-threatening complications.

 

6. Nail Psoriasis: Psoriasis can also affect the nails, causing pitting, discoloration, and separation of the nail from the nail bed.

 

7. Psoriatic Arthritis: Around 30% of people with psoriasis develop psoriatic arthritis, a condition that causes joint pain, swelling, and stiffness, potentially leading to permanent joint damage if left untreated.

 

The Emotional and Social Impact of Psoriasis

 

Living with psoriasis is not just a physical challenge but also an emotional and psychological burden. The visible nature of the disease can result in feelings of shame, embarrassment, and low self-esteem. Many individuals with psoriasis experience discrimination, misunderstandings, or even exclusion due to the appearance of their skin. For some, this can lead to social isolation and depression, significantly affecting their quality of life.

 

A survey conducted by IFPA revealed that nearly 50% of people living with psoriasis felt judged by others due to their condition. The emotional toll can be immense, as people with psoriasis are more prone to anxiety and depression compared to the general population. The stigma associated with visible skin conditions often exacerbates these feelings, making it essential to raise public awareness and promote understanding.

 

Psoriasis Treatment and Management

 

While there is no cure for psoriasis, various treatment options are available to help manage symptoms and improve the quality of life for individuals with the condition. Treatment plans typically depend on the severity and type of psoriasis, as well as the patient's overall health and preferences. Some of the most common treatment options include:

 

1. Topical Treatments: These are creams and ointments applied directly to the skin and are often the first line of defense for mild to moderate psoriasis. Common topical treatments include corticosteroids, vitamin D analogs, retinoids, and salicylic acid. These can reduce inflammation, slow skin cell production, and relieve itching.

 

2. Phototherapy (Light Therapy): In phototherapy, the skin is exposed to ultraviolet light under medical supervision. UVB light, which penetrates the skin’s upper layers, can help slow down skin cell growth and reduce symptoms. Natural sunlight can also be beneficial for some individuals with psoriasis.

 

3. Systemic Medications: For moderate to severe psoriasis, systemic treatments—medications that work throughout the body—may be prescribed. These can include oral or injected drugs such as methotrexate, cyclosporine, or biologics. Biologics target specific parts of the immune system, preventing it from attacking healthy skin cells. These treatments are often prescribed when other therapies are ineffective.

 

4. Lifestyle Modifications: Managing psoriasis often requires lifestyle changes. Stress management, a balanced diet, exercise, and avoiding triggers like smoking and alcohol can help reduce flare-ups. Moisturizing regularly is also essential to manage dry and irritated skin.

 

Challenges in Accessing Treatment

 

While effective treatments exist, access to them can be limited, particularly in low- and middle-income countries. A major goal of World Psoriasis Day is to draw attention to the disparities in healthcare access and advocate for better care for people living with psoriasis. Many individuals still lack access to appropriate medications or specialist care, which can worsen their condition and overall quality of life.

 

The cost of treatment is another significant barrier. Biologics, for example, are often expensive and may not be covered by insurance. For patients without access to these treatments, managing psoriasis can be a long and painful journey.

 

Raising Awareness and Fighting Stigma

 

World Psoriasis Day plays an essential role in educating the public, reducing stigma, and advocating for better health policies. Through campaigns, conferences, and social media initiatives, the day brings attention to the real-life challenges faced by those with psoriasis and promotes acceptance and empathy.

 

Advocates and organizations use the day to highlight the urgent need for more research, better healthcare policies, and comprehensive treatment plans that include mental health support. Campaigns often focus on themes such as “Uncovering Psoriasis” or “Breaking the Stigma,” which encourage individuals with psoriasis to share their stories and experiences, making the invisible struggles of psoriasis more visible to the world.

 

The Role of IFPA in Global Advocacy

 

The International Federation of Psoriasis Associations (IFPA) has been at the forefront of advocacy efforts for over 50 years. IFPA’s World Psoriasis Day is more than just an event—it’s a movement that aims to create global change. The organization pushes for the recognition of psoriasis as a serious non-communicable disease (NCD) and works with global health institutions like the World Health Organization (WHO) to improve healthcare access and reduce disparities.

 

IFPA’s efforts have led to significant milestones, including the WHO’s 2014 resolution recognizing psoriasis as a chronic, non-communicable, painful, and stigmatizing disease. The resolution highlighted the need for governments and health systems to take psoriasis more seriously and integrate it into their national health strategies.

 

How to Get Involved on World Psoriasis Day

 

World Psoriasis Day offers various ways for individuals, healthcare professionals, and organizations to get involved and make a difference. Here are some impactful actions that can be taken:

 

1. Education: Raise awareness by sharing facts and personal stories about psoriasis on social media platforms using hashtags like WorldPsoriasisDay. This helps inform others and reduce the stigma around the condition.

 

2. Advocacy: Encourage governments and healthcare providers to prioritize psoriasis treatment and mental health support for individuals affected by the disease.

 

3. Support: Participate in local or global fundraising campaigns, volunteer for organizations that support psoriasis patients, or join a psoriasis support group to provide emotional assistance to those in need.

 

4. Events: Many organizations host events, webinars, and awareness campaigns leading up to World Psoriasis Day. Participating in these activities amplifies the cause and fosters a sense of community.

 

Conclusion

 

World Psoriasis Day is more than just a day of awareness; it is a call to action for individuals, healthcare professionals, and policymakers to improve the lives of those living with psoriasis. By raising awareness, breaking stigmas, and advocating for better care, this global movement shines a light on the challenges faced by psoriasis patients and pushes for a more inclusive and understanding society. Everyone can play a role in supporting this cause, from spreading awareness to advocating for better healthcare policies, ultimately helping to create a world where people with psoriasis are treated with the respect and care they deserve.



Disclaimer: This material, including advice, provides general information only for educational purposes. It is in no way a substitute for a qualified medical opinion. Always consult a specialist or your doctor for more details. fittofitter.com does not claim responsibility for this information.

 

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